For women taking estrogen to manage the symptoms of menopause, research has suggested that the hormone may also protect the brain. Therefore, scientists have been interested in whether estrogen could reduce the risk or slow the progression of Alzheimer’s disease. Clinical trials with patients already diagnosed with Alzheimer’s disease, however, showed that estrogen had no impact on the progression of the disorder. Other studies have indicated that women who begin using estrogen after age 60 to 65 are at increased risk of developing dementia. Based on these findings, the U.S. Food and Drug Administration has recommended that women who choose to use hormone therapy (either estrogen alone or progestin plus estrogen) to help relieve the symptoms of menopause should take the medication for the shortest period of time at the lowest dose possible.
Recent research has helped clarify the neuroprotective role of estrogen taken by younger women before menopause. According to a study published in August 2007, scientists from the Mayo Clinic found that women who had one or both ovaries removed prior to menopause had an increased long-term risk of dementia or cognitive impairment. However, those who underwent ovary removal, but also had estrogen treatment until at least age 50 did not experience this higher risk. These findings suggest that if taken before menopause, the neuroprotective benefits of estrogen may outweigh the risks of side effects, such as heart problems, stroke and cognitive impairment.
Women of any age should consult with a physician about the individual risks and benefits of undergoing or considering hormone replacement therapy.
A thoughtful evaluation must be performed by a physician before taking any medications, over-the-counter drugs, supplements, or herbs. The American Health Assistance Foundation does not endorse any of these medications, vitamins, or herbs. A qualified physician should make an informed decision based on each person's medical history and current prescriptions. The medication summaries provided do not include all of the information important for patient use and should not be used as a substitute for professional medical advice. The prescribing physician should be consulted concerning any questions that you have.
The information provided in this section of our website was obtained from the National Institute on Aging.
Reviewed on 2/14/2007