Managing Plaques:
Beta-amyloid forms the insoluble deposits outside neurons that form the core of plaques, which are one of the hallmarks of Alzheimer’s disease. Researchers are developing drugs that prevent the formation of beta-amyloid, stop beta-amyloid from clumping together into plaques, and break beta-amyloid into pieces after it is released from cells before it has a chance to form into plaques.
Initial trials with a vaccine that will stimulate the immune system to stop the build-up of or facilitate the removal of beta-amyloid plaques in 2001 were halted when some of the participants in the study began to develop signs of brain inflammation. Although this was disappointing, a great deal was learned from the research and scientists are moving forward with other promising vaccine strategies.
Managing Tangles:
In healthy neurons, tau is a component of microtubules, which form part of the cell's structural support and deliver substances throughout the nerve cell. However, in Alzheimer’s disease, tau gets attached to molecules called phosphate groups and forms tangles, which consist of insoluble twisted fibers that are found inside of the brain's cells. Researchers are working to create drugs that can inhibit the production of these abnormal tau proteins.
A thoughtful evaluation must be performed by a physician before taking any medications, over-the-counter drugs, supplements, or herbs. The American Health Assistance Foundation does not endorse any of these medications, vitamins, or herbs. A qualified physician should make an informed decision based on each person's medical history and current prescriptions. The medication summaries provided do not include all of the information important for patient use and should not be used as a substitute for professional medical advice. The prescribing physician should be consulted concerning any questions that you have.
The information provided in this section of our website was obtained from the National Institute on Aging and the National Institute of Neurological Disorders and Stroke.
Reviewed on 2/14/2007