Alzheimer's Disease Research Grants

FUNDING PERIOD: APRIL 1, 2005 – MARCH 31, 2006

Gary E. Landreth, Ph.D.
Case Western Reserve University
Cleveland, OH
Project: Mechanisms of Microglial-mediated Oxidative Damage in AD
$147,176

FUNDING PERIOD: APRIL 1, 2005 – MARCH 31, 2006

Gary Landreth, Ph.D.
Case Western Reserve University
Cleveland, OH
Project: Mechanisms of Microglial-mediated Oxidative Damage in Alzheimer’s Disease

There is good evidence that neurons in the AD brain have experienced oxidative damage, impairing the function of neuronal proteins, lipids and DNA. The microglial enzyme that produces free oxygen radicals is termed NADPH oxidase, and has to be assembled from several subunits to be active. Amyloid fibrils have been found to stimulate assembly of this oxidase. One goal of Dr. Landreth’s study is to understand how the binding of amyloid fibrils to the cell results in assembly and activation of the NADPH oxidase. His studies will determine if knocking out the oxidase results in lower levels of oxidative damage in an AD mouse model. These studies are of therapeutic importance as anti-oxidants are currently being considered for the treatment of AD.

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