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Kathryn Moore, Ph.D.
Massachusetts General Hospital
Boston, MA
Title:
Innate immune signaling in Alzheimer's disease pathogenesis
Non-Technical Title:
Role of the innate immune response in the development of Alzheimer's disease
Duration:
April 1, 2008 - March 31, 2011
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Summary: This award seeks to study the role of the innate immune system in AD pathogenesis. and the role of Toll-like recceptors in mediating the microglial inflammatory response. Microglia likely play a key role in the clearance of Aß as well as in more chronic inflammatory changes as a result of Aß activation.
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Program: Alzheimer's Disease
Award Type: Standard
$265,000
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Robert Nichols, Ph.D.
Drexel University
Philadelphia, PA
Title:
Beta Amyloid Regulation of Presynaptic Nicotinic Current
Non-Technical Title:
Understanding the normal functions of Amyloid Beta
Duration:
April 1, 2007 - March 31, 2010
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Summary: This project is aimed at understanding the physiological role of Amyloid beta. Using a defined nerve cell system in culture, we can express target protein receptors for beta amyloid and then examine the functional consequence via several techniques. We can also introduce mutations into the receptors or make deletions to define precisely the molecular components targeted by beta amyloid. Finally, we can explore derivatives of beta amyloid as potential means to disrupt beta amyloid’s action
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Program: Alzheimer's Disease
Award Type: Pilot
$145,059
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Marguerite Prior, Ph.D.
The Cleveland Clinic Foundation
Cleveland, OH
Title:
Inhibition of RTN3 aggregation as a novel therapeutic target to reduce cognitive failure in AD
Non-Technical Title:
Novel therapeutic target to reduce cognitive failure in AD
Duration:
April 1, 2008 - March 31, 2010
Mentor:
Riqiang Yan, Ph.D.
The Cleveland Clinic Foundation
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Summary: This study hypothesizes that aggregation of a BACE inhibitor (RTN3) may lead to increased levels of amyloid beta. By defining a class of potential inhibitors of RTN3 aggregation, this proposal seeks to determine a new class of therapeutic interventions against Alzheimer's disease.
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Program: Alzheimer's Disease
Award Type: Research Fellowship
$100,000
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Wolfgang Quitschke, Ph.D.
State University of New York at Stony Brook
Stony Brook, NY
Title:
Effect Of Serum-Solubilized Curcumin On Plaques In Alzheimer’s Disease Transgenic Mice
Non-Technical Title:
Effect Of Injectable Derivatives Of The Turmeric Spice On Plaques In AD Transgenic Mice
Duration:
April 1, 2009 - March 31, 2011
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Summary: Experimentally, curcumin (turmeric spice) has been implicated in resolving and preventing Alzheimer’s disease associated plaques or deposits both in living systems and in test tubes. Epidemiological data suggest that the consumption of curcumin is linked to a lower incidence of Alzheimer’s disease. However, the solubility of curcuminc in watery solutions is exceedingly low, which limits its systemic absorption and therapeutic potential. A new method is proposed to treat or prevent amyloid plaque formation associated with Alzheimer’s disease by injection of highly concentrated blood serum-solubilized curcumin.
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Program: Alzheimer's Disease
Award Type: Pilot
$104,762
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Anton Roebroek, Ph.D.
Katholieke Universiteit Leuven
Leuven, Belgium
Title:
The Dual Role of LRP1 in Generation and Clearance of Ab
Non-Technical Title:
Role of LRP1 in production and degradation of ABeta
Duration:
April 1, 2007 - March 31, 2010
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Summary: Recent scientific investigations revealed that a receptor, LRP1, present on the outside of the cells in the brain might be involved at the same time in both production and breakdown of Ab. Lately, the applicant of the research project generated mice and cells with a modified LRP1, which can be used to clarify the double role of LRP1 in Ab metabolism.
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Program: Alzheimer's Disease
Award Type: Standard
$240,000
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Troy Rohn, Ph.D.
Boise State University
Boise, ID
Title:
Caspase-cleavage of Tau in Alzheimer's disease
Non-Technical Title:
Understanding relationship between ABeta and Tau in tangle formation
Duration:
April 1, 2007 - March 31, 2010
Co-Investigator(s):
Wayne Poon, Ph.D.
University of California - Irvine
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Summary: Direct, functional evidence for the involvement of caspases in driving AD pathology is currently lacking. The current proposal will test directly the role of caspases in AD by blocking caspase activation in an AD transgenic mouse model and examining whether such inhibition prevents the pathology associated with these animals.
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Program: Alzheimer's Disease
Award Type: Pilot
$131,140
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Terrone Rosenberry, Ph.D.
Mayo Clinic Jacksonville
Jacksonville, FL
Title:
Detection of cross-linked amyloid-beta oligomers in Alzheimer's disease by mass spectrometry
Non-Technical Title:
Is a specific chemical modification of amyloid beta-peptides important in Alzheimer's disease?
Duration:
April 1, 2008 - June 30, 2010
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Summary: This study seeks to determine some of the mechanisms by which amyloid beta aggregates and ultimately how these aggregates work to assemble in amyloid plaques. Using a systematic approach, Dr. Rosenberry's team is working on developing ways of studying these aggregates that exist at extremely low concentrations in the brain.
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Program: Alzheimer's Disease
Award Type: Pilot
$150,000
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Paul Salvaterra, Ph.D.
Beckman Research Institute of the City of Hope
Duarte, CA
Title:
Ab and Neurodegeneration
Non-Technical Title:
Ab and neurodegeneration
Duration:
April 1, 2007 - March 31, 2010
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Summary: Our work is designed to investigate the role of certain peptides, both alone and in combination, as direct causes of chronic brain cell death. We will accomplish this by using a simplified genetically controlled model organism. We also believe that our preliminary observations indicate a new cellular pathway that may be responsible for Alzheimer's related cell death. We will thus try and prove this hypothesis using genetic and drug based experimental strategies in our model system.
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Program: Alzheimer's Disease
Award Type: Standard
$400,000
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Eric Schon, Ph.D.
Columbia University
New York, NY
Title:
ER-Mitochondrial interactions in familial Alzheimer's disease
Non-Technical Title:
Mitochondrial defects in familial Alzheimer’s disease
Duration:
April 1, 2008 - March 31, 2010
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Summary:
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Program: Alzheimer's Disease
Award Type: Pilot
$150,000
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Vijay Sharma, Ph.D.
Washington University
St. Louis, MO
Title:
Imaging PGP-Mediated Transport in Alzheimer's Disease
Non-Technical Title:
Improving imaging tools for diagnosis of AD
Duration:
April 1, 2007 - March 31, 2010
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Summary: We propose to evaluate the potential of lead Pgp-targeted agent to act as noninvasive probe to detect those defects in brains of mouse models via PET imaging. Additionally, our strategy is amenable to kit formulation with potential for widespread deployment of a test for managing AD.
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Program: Alzheimer's Disease
Award Type: Pilot
$150,000
