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Xuemin Xu, Ph.D.
The University of Tennessee, College of Veterinary Medicine
Knoxville, TN
Title:
Vascular Risk Factors In Alzheimer's Disease
Non-Technical Title:
How Heart Disease Risk Factors Cause Alzheimer's Disease
Duration:
April 1, 2009 - March 31, 2012
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Summary: The proposed study investigates the mechanism by which oxidized lipids up-regulate the expression of Beta-secretase, which is a key enzyme in the generation of amyloid-beta from amyloid precursor protein (APP). Amyloid beta is the key molecule in the development of Alzheimer’s disease (AD) in both test-tube and living systems. The success of the proposed study will provide novel insight into the roles of oxidized lipids, the major vascular risk factors, in the development of amyloidogenesis as well as their direct neurotoxicities. The information may lead to the identification of novel therapeutic targets for preventing and curing oxidative stress-induced neurodegenerative diseases.
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Program: Alzheimer's Disease
Award Type: Standard
$400,000
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Huaxi Xu, Ph.D.
Burnham Institute for Medical Research
La Jolla, CA
Title:
Roles of a novel gene FG01 in inhibiting Alzheimer's amyloid and tau pathologies and GSK3 activity
Non-Technical Title:
Identification and characterization of a novel gene that inhibits Alzheimer's amyloid and tau pathology
Duration:
April 1, 2008 - March 31, 2011
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Summary: This investigator has discovered a novel gene, FG01, that can significantly reduce ABeta by interfering with gamma secretase. However, this is accomplished without side effects caused by inhibiting other gamma-secretase activities. This project will continue to characterize the functions of this gene to understand its mechanism of action, and may eventually be applied to develop therapeutic interventions specifically inhibiting ABeta without unwanted side-effects.
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Program: Alzheimer's Disease
Award Type: Standard
$400,000
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Jiaqi Yao, M.D., Ph.D.
Weill Medical College of Cornell University
New York, NY
Title:
The Role Of Actin Cytoskeletal Pathology In Alzheimer's Disease
Non-Technical Title:
Abnormal Changes Of The Actin Cytoskeleton Play Crucial Roles In Alzheimer's Disease
Duration:
April 1, 2009 - March 31, 2011
Mentor:
M. Flint Beal, M.D.
Joan and Sanford I. Weill Medical College of Cornell University
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Summary: To investigate mechanisms and consequences of abnormal alterations of the actin cytoskeleton, which may play critical roles in Alzheimer’s disease (AD) causes and development. The proposed project focuses on a field that is largely unknown and will help us to understand the pathological development of AD from a fresh point of view.
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Program: Alzheimer's Disease
Award Type: Research Fellowship
$100,000
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Jerry Chi-Ping Yin, Ph.D.
Board of Regents of the University of Wisconsin System
Madison, WI
Title:
Sleep And The Suppression Of Abeta-Mediated Phenotypes
Non-Technical Title:
Sleep And Alzheimer's Disease
Duration:
April 1, 2009 - March 31, 2011
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Summary: Because of the rapid life spans and small size, fruit flies are used by many biologists to study complex genetics. In a fruit-fly model for Alzheimer's disease, sleep is disrupted at birth, preceding all of the other symptoms. Can increasing sleep, or decreasing the stresses of wakefulness, improve some of the later-onset disease symptoms? We will use pharmacological and genetic approaches to answer this question.
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Program: Alzheimer's Disease
Award Type: Pilot
$300,000
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Fang Yu, PhD
University of Minnesota
Minneapolis, MN
Title:
Feasibility Of Aerobic Exercise In Alzheimer's Disease
Non-Technical Title:
Feasibility And Impact Of Studying Aerobic Exercise In Alzheimer's Disease
Duration:
April 1, 2009 - March 31, 2011
Co-Investigator(s):
Maurice Dysken, M.D.
Minneapolis VA Medical Center
Patricia Painter, Ph.D.
University of Minnesota
Jean Wyman, Ph.D.
University of Minnesota
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Summary: Aerobic exercise training is a promising intervention that does not rely on drugs for slowing the progression of Alzheimer's disease (AD) symptoms such as cognitive impairment, decline in activities of daily living, and behavioral and psychological symptoms of dementia. Our study will determine the feasibility of recruiting and retaining 30 community-dwelling persons with AD to participate in a 6-month, individualized, moderate-intensity aerobic exercise program (cycling on recumbent stationary cycles) at community gyms. This study is expected to provide data to design and implement future randomized controlled trials to test the effects of aerobic exercise training in AD and will facilitate the development of aerobic exercise prescription guidelines in AD.
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Program: Alzheimer's Disease
Award Type: Pilot
$150,000
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Hui Zheng, Ph.D.
Baylor College of Medicine
Houston, TX
Title:
Role of APP in synaptogenesis
Non-Technical Title:
Amyloid precursor protein in synapse regulation
Duration:
April 1, 2008 - August 31, 2011
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Summary: Synapse dysfunction triggered by ABeta is central to Alzheimer's disease progression. While ABeta is derived from processing of APP, a physiological function for APP has not been clearly defined. This project will provide fundamental insights into Alzheimer's disease by providing a better understanding of synaptic roles for APP and of the mechanisms by which AB generation interferes with normal APP function.
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Program: Alzheimer's Disease
Award Type: Standard
$400,000
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Daniel Zwilling, Ph.D.
J. David Gladstone Institutes
San Francisco, CA
Title:
The Role of the Kynurenine Pathway in Microglia in Alzheimer's Disease
Non-Technical Title:
How immune cells of the brain contribute to Alzheimer's disease
Duration:
April 1, 2008 - March 31, 2010
Mentor:
Paul Muchowski, Ph.D.
J. David Gladstone Institutes
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Summary: The major goal of this proposal is to use genetic and pharmacological approaches in mouse models of Alzheimer's disease to characterize the contribution of the microglial kynureine pathway to the pathogenesis of AD which may potentially contribute to the current understanding of pathogenesis of AD and provide new treatments.
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Program: Alzheimer's Disease
Award Type: Research Fellowship
$100,000
