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Jiaqi Yao, M.D., Ph.D.
Weill Medical College of Cornell University
New York, NY
Title:
The Role Of Actin Cytoskeletal Pathology In Alzheimer's Disease
Non-Technical Title:
Abnormal Changes Of The Actin Cytoskeleton Play Crucial Roles In Alzheimer's Disease
Duration:
April 1, 2009 - March 31, 2011
Mentor:
M. Flint Beal, M.D.
Joan and Sanford I. Weill Medical College of Cornell University
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Summary: To investigate mechanisms and consequences of abnormal alterations of the actin cytoskeleton, which may play critical roles in Alzheimer’s disease (AD) causes and development. The proposed project focuses on a field that is largely unknown and will help us to understand the pathological development of AD from a fresh point of view.
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Program: Alzheimer's Disease
Award Type: Research Fellowship
$100,000
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Jerry Chi-Ping Yin, Ph.D.
Board of Regents of the University of Wisconsin System
Madison, WI
Title:
Sleep And The Suppression Of Abeta-Mediated Phenotypes
Non-Technical Title:
Sleep And Alzheimer's Disease
Duration:
April 1, 2009 - March 31, 2011
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Summary: Because of the rapid life spans and small size, fruit flies are used by many biologists to study complex genetics. In a fruit-fly model for Alzheimer's disease, sleep is disrupted at birth, preceding all of the other symptoms. Can increasing sleep, or decreasing the stresses of wakefulness, improve some of the later-onset disease symptoms? We will use pharmacological and genetic approaches to answer this question.
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Program: Alzheimer's Disease
Award Type: Pilot
$300,000
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Tracy Young-Pearse, Ph.D.
Brigham and Women's Hospital
Title:
APP Function in the Brain: Novel Interactions with Pancortin
Non-Technical Title:
Towards an Undertanding of How the Toxic Species in Alzheimer's Disease is Produced
Duration:
July 1, 2009 - March 31, 2011
Mentor:
Dennis Selkoe, M.D.
Brigham and Women's Hospital
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Summary: I aim to address the normal function and signaling pathways surrounding APP in the central nervous system. We have identified Pancortins as putative ligands for APP in the central nervous system, and I aim to determine to what extent Pancortins affect APP cleavage and amyloid beta production.
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Program: Alzheimer's Disease
Award Type: Research Fellowship
$87,500
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Fang Yu, PhD
University of Minnesota
Minneapolis, MN
Title:
Feasibility Of Aerobic Exercise In Alzheimer's Disease
Non-Technical Title:
Feasibility And Impact Of Studying Aerobic Exercise In Alzheimer's Disease
Duration:
April 1, 2009 - March 31, 2011
Co-Investigator(s):
Maurice Dysken, M.D.
Minneapolis VA Medical Center
Patricia Painter, Ph.D.
University of Minnesota
Jean Wyman, Ph.D.
University of Minnesota
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Summary: Aerobic exercise training is a promising intervention that does not rely on drugs for slowing the progression of Alzheimer's disease (AD) symptoms such as cognitive impairment, decline in activities of daily living, and behavioral and psychological symptoms of dementia. Our study will determine the feasibility of recruiting and retaining 30 community-dwelling persons with AD to participate in a 6-month, individualized, moderate-intensity aerobic exercise program (cycling on recumbent stationary cycles) at community gyms. This study is expected to provide data to design and implement future randomized controlled trials to test the effects of aerobic exercise training in AD and will facilitate the development of aerobic exercise prescription guidelines in AD.
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Program: Alzheimer's Disease
Award Type: Pilot
$150,000
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Hui Zheng, Ph.D.
Baylor College of Medicine
Houston, TX
Title:
Role of APP in synaptogenesis
Non-Technical Title:
Amyloid precursor protein in synapse regulation
Duration:
April 1, 2008 - August 31, 2011
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Summary: Synapse dysfunction triggered by ABeta is central to Alzheimer's disease progression. While ABeta is derived from processing of APP, a physiological function for APP has not been clearly defined. This project will provide fundamental insights into Alzheimer's disease by providing a better understanding of synaptic roles for APP and of the mechanisms by which AB generation interferes with normal APP function.
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Program: Alzheimer's Disease
Award Type: Standard
$400,000
