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Macular Degeneration Research - Current Awards
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Steve Abcouwer, Ph.D.
The Pennsylvania State University
Hershey, PA
Title: Effect of Mutant Fibulin Expression on RPE Cell Function
Non-Technical Title: Testing the role of the fibulin gene in retinal degeneration
Duration: April 1, 2006 - March 31, 2009
Award Type: Standard
$100,000 |
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We hypothesize that the expression of mutant fibulin proteins compromises the ability of RPE cells to perform one of their primary functions, swallowing and processing of outer segments that are shed from photoreceptor cells. Evidence suggests that the rate of outer segments shedding and the ability of the RPE to remove and process the outer segments are key factors in the progression of AMD. The proposed studies would expand our understanding of these vital RPE functions, and could point the way to AMD treatments that act by alleviating protein aggregation.
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Jayakrishna Ambati, M.D.
University of Kentucky Research Foundation
Lexington, KY
Title: Adeno-associated viral gene therapy in a novel mouse model of AMD
Non-Technical Title: Gene therapy for AMD
Duration: April 1, 2004 - June 30, 2008
Award Type: Standard
$100,000 |
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This project uses viral gene therapy in mice to repair genetic defects that lead to AMD like pathology.
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Jayakrishna Ambati, M.D.
University of Kentucky Research Foundation
Lexington, KY
Title: The Role of SPARC in Macular Propensity for CNV
Non-Technical Title: The role of SPARC protein in new blood vessel growth
Duration: April 1, 2007 - March 31, 2009
Award Type: Standard
$100,000 |
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This study will characterize SPARC protein characteristics in patients with and without AMD and further test the utility of inhibiting SPARC to reduce new blood vessel growth in animal models.
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Chi-Chao Chan, M.D.
The National Eye Institute
Bethesda, MD
Title: Chaperone and Age-Related Macular Degeneration Model
Non-Technical Title: Using mouse genetics to understand AMD
Duration: April 1, 2007 - March 31, 2009
Award Type: Standard
$100,000 |
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These investigators have established a genetically distinct mouse lineage that develops many features similar to AMD. By studying these mice, the investigators hope to learn more about the causes of AMD and potentially suggest new therapies.
More details |
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Qiuyun Chen, Ph.D.
The Cleveland Clinic Foundation
Cleveland, OH
Title: Identification of Human Retinal Lutein Binding Proteins
Non-Technical Title: Determining ways to modulate lutein levels in the eye
Duration: April 1, 2006 - March 31, 2009
Award Type: Standard
$200,000 |
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These investigators will identify lutein binding proteins from human retina by searching for genes that when expressed will produce proteins that specifically bind lutein. Once the gene(s) are identified, we will determine what type of proteins they are and whether their distribution in the retina correlates with the lutein distribution pattern.
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Qiuyun Chen, Ph.D.
Lerner Research Institute
Cleveland, OH
Title: Identification of human retinal lutein binding proteins
Non-Technical Title: Determining ways to modulate lutein levels in the eye
Duration: April 1, 2006 - March 31, 2008
Award Type: Standard
$100,000 |
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These investigators will identify lutein binding proteins from human retina by searching for genes that when expressed will produce proteins that specifically bind lutein. Once the gene(s) are identified, we will determine what type of proteins they are and whether their distribution in the retina correlates with the lutein distribution pattern.
More details |
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Dequan Chen, Ph.D.
Mayo Clinic
Rochester, MN
Title: The gene structure of ARMS2/LOC387715 and its expression in human eyes
Non-Technical Title: Gene structure and expression of ARMS2
Duration: April 1, 2008 - March 31, 2010
Award Type: Standard
$100,000 |
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This study will examine a region of chromosome 10 that has been linked to AMD. This study seeks to identify all genes located in this region, and whether they are differentially expressed when AMD and non AMD eyes are compared.
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Anne Coleman, M.D., Ph.D.
University of California, Los Angeles
Los Angeles, CA
Title: Single Nucleotide Polymorphisms and AMD in Older Women
Non-Technical Title: Genetics of bone disease and AMD in older women
Duration: April 1, 2007 - March 31, 2009
Award Type: Standard
$100,000 |
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These experiments seek to determine whether genes related to bone metabolism are associated with risk of AMD
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XiQin Ding, Ph.D.
University of Health Sciences Ctr
Oklahoma City, OK
Title: Molecular Defects of the Cone CNG Channel Mutations
Non-Technical Title:
Duration: April 1, 2006 - March 31, 2008
Award Type: Standard
$100,000 |
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More details
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Elia Duh, M.D.
JHU School of Medicine
Baltimore, MD
Title: Regulation of angiogenesis in CNV by the Akt/Forkhead
Non-Technical Title:
Acknowledgements: Partial funding for this award is from the Testamentary Trust of Alma V. Sharrer, deceased. MDR 2006
Duration: April 1, 2006 - March 31, 2008
Award Type: Standard
$200,000 |
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More details
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Last Reviewed On: 09/26/08
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