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Dennis Schultz, Ph.D.
Oregon Health and Science University
Portland, OR
Title:
Characterization of 10q26 AMD Protein
Non-Technical Title:
Characterization of novel protein on human chromosome 10
Duration:
April 1, 2007 - March 31, 2010
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Summary: This study will examine a previously uncharacterized protein from a region of the genome believed to be linked to AMD
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Program: Macular Degeneration
Award Type: Standard
$100,000
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Justine Smith, M.D., Ph.D.
Oregon Health and Science University
Portland, OR
Title:
Novel Molecular Regulators of Choroidal Neovascularization in Age-Related Macular Degeneration
Non-Technical Title:
Control of New Blood Vessel Growth in Macular Degeneration
Duration:
April 1, 2008 - March 31, 2010
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Summary: This research group has developed a technique for isolation of endothelial cells of the choroid from human eyes that are supplied by the Lions Eye Bank of Oregon. In this project, they will study three molecules that are produced at high levels in tissues related to AMD. They will test the ability of these molecules to control the formation of new blood vessels.
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Program: Macular Degeneration
Award Type: Standard
$100,000
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Dwight Stambolian, M.D., Ph.D.
University of Pennsylvania
Philadelphia, PA
Title:
Potential Therapy of Age-Related Macular Degeneration with Small Molecules
Non-Technical Title:
Small molecule therapy for Macular Degeneration
Duration:
April 1, 2008 - March 31, 2010
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Summary: This project is looking for a small molecule which can penetrate the eye and diminish the eye inflammation that occurs in AMD. If successful, this small molecule can be administered at the earlier stages of AMD to halt progression to the later stages and eventual blindness. In order to identify such a molecule, we will screen a small molecule library and confirm its efficacy in a test tube before moving onto animal models.
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Program: Macular Degeneration
Award Type: Standard
$100,000
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Jeffrey Stern, M.D., Ph.D.
Regenerative Research Foundation
Rensselaer, NY
Title:
alphaB-crystallin and the Amyloid-beta mediated RPE stress response in Age related Macular Degeneration
Non-Technical Title:
The role of Alzheimer Disease protein and the stress response in AMD
Duration:
April 1, 2008 - March 31, 2010
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Summary: A protein related to Alzheimer's disease is known to be present in cases of AMD. This proposal will examine a toxic product of this protein and ask whether it is involved in the development of AMD.
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Program: Macular Degeneration
Award Type: Standard
$100,000
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Allen Taylor, Ph.D.
Tufts University School of Medicine
Boston, MA
Title:
Carbohydrate, Dietary Patterns and AMD risk in 2 Cohorts
Non-Technical Title:
What diets place people at risk for developing AMD?
Duration:
April 1, 2007 - September 30, 2009
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Summary: This project uses data from a number of large studies to test whether limiting carbohydrates reduces risk of developing AMD
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Program: Macular Degeneration
Award Type: Standard
$100,000
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Sally Temple, Ph.D.
Regenerative Research Foundation
Rensselaer, NY
Title:
The role of Sox2 in AMD
Non-Technical Title:
The role of a critical eye development gene, SOX2, in Age-related Macular Degeneration
Duration:
April 1, 2008 - March 31, 2010
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Summary: This study will determine whether Sox2 is expressed in the retina of patients with AMD and the consequence of varying its concentration. This research will contribute to understanding the progression of AMD, and help identify ways to slow or even halt its advance.
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Program: Macular Degeneration
Award Type: Standard
$100,000
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Derek van der Kooy, Ph.D.
University of Toronto
Toronto, Ontario, Canada
Title:
Retinal Stem Cells for Transplantation in Macular Degeneration
Non-Technical Title:
Retinal Stem Cells for Transplantation in Macular Degeneration
Duration:
April 1, 2008 - March 31, 2010
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Summary: In this study, the researchers will isolate mouse adult retinal stem cells and enrich them for cone photoreceptors by manipulating specific cellular pathways as through a cell sorting technique. They will also test the ability of transplanted adult retinal stem cells to restore vision in mice that lack functioning cone photoreceptors.
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Program: Macular Degeneration
Award Type: Standard
$100,000
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Zhenglin Yang, M.D.
University of California, San Diego
La Jolla, CA
Title:
Functional Study of HTRA1 and Age-related Macular Degeneration
Non-Technical Title:
Etiology and Pathogenesis of Age-related Macular Degeneration
Duration:
April 1, 2008 - March 31, 2010
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Summary: Identification and functional studies of the HTRA1, a gene that has substantial impact on the risk of AMD, may define key molecular pathways involved in its pathogenesis. The experiments will yield novel mechanistic insights relevant to the pathogenesis of both early and late AMD. This may lead to therapies directed at the underlying cause and pre-symptomatic diagnosis leading to earlier intervention.
More details
Program: Macular Degeneration
Award Type: Standard
$100,000
