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National Glaucoma Research - Current Award

Dr. Paul Knepper

Paul A. Knepper, M.D., Ph.D.

University of Illinois at Chicago
Chicago, IL, United States

Title: Activation of Innate Immune Toll-4 Receptor in POAG
Non-Technical Title: Activation of Innate Immunity System and Gluacoma

Acknowledgements: Recipient of the Thomas R. Lee award for National Glaucoma Research
Duration: July 1, 2011 - June 30, 2013
Award Type: Standard
Award Amount: $100,000


Summary:

We have identified a unified signaling pathway based on activation of innate immune system which results in an inflammatory cascade resulting in POAG. We have identified that cell trauma causes low-molecular-weight hyaluronic acid to start the pathway. Prevention of degradation of high-molecular-weight hyaluronic acid by potent hyaluronidase inhibitor could be novel therapy and the first therapy directly aimed at the cause of POAG.

Details:

Hyaluronic acid is a long-chain sugar polymer that is naturally present at high concentrations in the fluids of the eye and joints. Inflammation and cell damage in the eye will cut hyaluronic acid into smaller pieces (called low molecular weight hyaluronic acids which are pro-inflammatory) and this can tip the balance towards primary open-angle glaucoma (POAG). Dr. Knepper and colleagues will collect and test samples of the aqueous humor (found in the eye cavity in between the cornea and the lens) of people who are either healthy or who have POAG. The results of this study could lead to the design of a drug to prevent the hyaluronic acid from becoming cut into small pieces. This could be the first treatment that targets the underlying cause of POAG, rather than just managing the symptoms of the disease.

Investigator Biography:

Dr. Knepper is an ophthalmologist and cell biologist at the University of Illinois at Chicgo and Northwestern University Medical School. Dr. Knepper laboratory has discovered several biomarkers of the glaucoma process which has lead to a possible pathway for understanding the cause and novel treatments of the disease. The AHAF grant will enable his research team to test the new unified pathway and explore new treatment modalities based on the innate immune system.