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National Glaucoma Research - Current Award

Dr. Alan Marmorstein

Alan Marmorstein, Ph.D.

University of Arizona
Tucson, AZ

Title: Bestrophin-2 And Aqueous Humor Dynamics
Non-Technical Title: Bestrophin-2 Protein And Glaucoma

Acknowledgements: Recipient of the Thomas R. Lee award for National Glaucoma Research
Duration: April 1, 2009 - March 31, 2011
Award Type: Standard
Award Amount: $100,000


Summary:

This study seeks to determine how the Bestrophin-2 protein controls the flow of the fluid in the eye, the aqueous humor.

Details:

We have recently identified the Bestrophin-2 protein (Best2) as a key regulator of fluid dynamics in the eye. This study will determine, via two specific aims, the mechanisms underlying this unique activity. If successful, this study will lead to new therapeutic options for treatment of glaucoma. Specific aims are 1. To determine how Best2 functions to antagonize the formation of aqueous humor, the fluid found in the eye. 2. To determine how absence of Best2 enhances outflow of aqueous humor from the eye.