Text Size Normal Text Sizing Button Medium Text Sizing Button Large Text Sizing Button Text Contrast Normal Contrast Button Reverse Contrast Button Switch to Spanish Language Press Room Contact Us Sitemap Sign In Register
Link to Homepage About AHAF
Donate Now Get Involved  
Alzheimer's Disease Research Macular Degeneration Research National Glaucoma Research


Sign up for Email Notifications
If you would like to be notified when submission deadlines are announced please click on the link below.

Sign up for new RFP announcements and submission deadline notifications.

This email list is not sold or distributed, and serves only as an annual reminder of the availability of research funding through the American Health Assistance Foundation (www.ahaf.org). Please follow instructions on the notification emails for removal requests.
 
Researchers:
Have you heard a story, statistic, or discovery that might interest the public? Let us know about it!
 
AHAF Research Grants Funding
Grant Funding for Alzheimer's Research
Grant Funding for Macular Degeneration Research
Grant Funding for Glaucoma Research
 

  

Alzheimer's Disease Research - Current Award

Dr. Zhefeng Guo

Zhefeng Guo, Ph.D.

University of California, Los Angeles
Los Angeles, CA

Title: EPR studies of the structures of Abeta oligomers
Non-Technical Title: Mechanisms of neurotoxicity in Alzheimer's disease

Duration: April 1, 2010 - March 31, 2012
Award Type: Pilot
Award Amount: $150,000


Summary:

Recent studies suggest that amyloid beta oligomers, or aggregation of only a few amyloid beta molecules, are the primary toxic species in the development of Alzheimer's disease. In this project, we will study the structures of two amyloid beta oligomers with electron paramagnetic resonance (EPR) spectroscopy. This work will help understand the structural basis of neurotoxicity of amyloid beta oligomers and guide the development of new therapeutic strategies.

Details:

Recent studies suggest that amyloid beta oligomers are the primary toxic species in the development of Alzheimer's disease. Different amyloid beta oligomers have been identified by different investigators. Because the molecular structures of these oligomers are unknown, it is impossible to know how many unique structures exist in the oligomers and how one type of oligomer differs from another type of oligomer. In this project, we will study the structures of two amyloid beta oligomers with a technique called electron paramagnetic resonance (EPR) spectroscopy. This work will help understand the structural basis of toxicity of amyloid beta oligomers and guide the development of new therapeutic strategies. Our experimental approach involves introducing a probe called spin label into the sequence of amyloid beta. Spin label gives rise to an “EPR spectrum”, from which structural information can be extracted. The distance between two spin labels can also be measured. These distances will serve as constraints for computation of structural models of these oligomers. EPR is a powerful technique for protein structure studies, but its application in Alzheimer's disease has been limited. We plan to explore the applications of existing EPR methods and develop new strategies to study these amyloid beta oligomers. Success in this project will pave the way for more extensive studies of not only Alzheimer's disease, but also other similar neurodegenerative diseases.