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National Glaucoma Research - Completed Award

Photo Pending

Beatrice Yue, Ph.D.

University of Illinois at Chicago
Chicago, IL

Title: Functional Roles of Optineurin in RGC-5 cells
Non-Technical Title: Functions of Optineurin, a Glaucoma Gene

Duration: April 1, 2008 - March 31, 2010
Award Type: Standard
Award Amount: $100,000


Summary:

This study examines how proteins are transported inside cells and how neurites grow. The study may enhance understanding of mechanisms leading to neuronal cell loss in glaucoma and facilitate development of new treatments for glaucoma.

Details:


The researchers will study the roles of optineurin, a glaucoma gene, in two cellular functions in neuronal cells. One functions relates to the transportation of proteins inside cells, and the other governs whether and how neurites extend or grow in the cells. This study will provide new information about the role of optineurin in these important functions. It should also help explain why and how abnormal levels or mutations of optineurin may lead to glaucoma. The study may enhance understanding of mechanisms leading to neuronal cell loss in glaucoma and facilitate development of new treatments for glaucoma.

Publications:

Koga, T., Shen, X., Park, J., Qiu, Y., Park, B.C., Shyam, R. and Yue, B.Y.J.T. (2010) Differential Effects of Myocilin and Optineurin, Two Glaucoma Genes, on Neurite Outgrowth. Am. J. Pathol. 176, 343-352 PubMed Icon Google Scholar Icon

Ying, H., Shen, X., Park, B.C. and Yue, B.Y.J.T. (2010) Posttranslational modification, localization and protein protein interactions of optineurin. PLoS One 5:e9168. PubMed Icon Google Scholar Icon