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Macular Degeneration Research - Current Award

Photo Pending

Michael Gorin, M.D., Ph.D.

University of California, Los Angeles
Los Angeles, CA

Title: Linkage and Association Studies for Macular Degeneration
Non-Technical Title: Genetics of AMD

Co-Investigator(s):
Daniel Weeks, Ph.D.
University of Pittsburgh
Yvette Conley, Ph.D.
University of Pittsburgh

Duration: April 1, 2006 - March 31, 2010
Award Type: Standard
Award Amount: $150,000


Summary:

We are investigating the genetic variations that contribute to ARM so that we can eventually understand the causes of this complex condition. We study the genetic variations that are shared among ARM-affected individuals within families as well as compare the frequencies of genetic variations in ARM-affected individuals with those in unaffected persons who are matched in age, gender, and exposures.

Details:

Age-related macular degeneration (ARM) is a major cause of vision loss in the elderly. It is thought that smoking and diet may contribute to the risk of developing the condition but it is clear that heredity plays a major role. Variations in two genes, CFH and PLEKHA1/LOC387715, have been found to strongly contribute to the risk of developing ARM, but there are additional genes that probably influence a person’s chances of having this condition and how they will progress to vision loss. We are investigating the genetic variations that contribute to ARM so that we can eventually understand the causes of this complex condition. We study the genetic variations that are shared among ARM-affected individuals within families as well as compare the frequencies of genetic variations in ARM-affected individuals with those in unaffected persons who are matched in age, gender, and exposures. Our long-term goals are to develop new preventive therapies that can slow or halt the development of this disease and to be able to provide these treatments to those who are at greatest risk before they experience vision-threatening changes.