Text Size Normal Text Sizing Button Medium Text Sizing Button Large Text Sizing Button Text Contrast Normal Contrast Button Reverse Contrast Button Switch to Spanish Language Contact Us Sitemap Sign In Register
Link to Homepage About AHAF
Donate Now Get Involved  
Alzheimer's Disease Research Macular Degeneration Research National Glaucoma Research


Sign up for Email Notifications
If you would like to be notified when submission deadlines are announced please click on the link below.

Sign up for new RFP announcements and submission deadline notifications.

This email list is not sold or distributed, and serves only as an annual reminder of the availability of research funding through the American Health Assistance Foundation (www.ahaf.org). Please follow instructions on the notification emails for removal requests.
 
AHAF Research Grants Funding
Grant Funding for Alzheimer's Research
Grant Funding for Macular Degeneration Research
Grant Funding for Glaucoma Research
 

  

Alzheimer's Disease Research - Current Award

Dr. Bruce Lamb

Bruce Lamb, Ph.D.

The Cleveland Clinic Foundation
Cleveland, OH

Title: Microglia , CX3CR1and Alzheimer's Disease Pathogenesis
Non-Technical Title: Activation of the immune system in AD

Duration: April 1, 2007 - March 31, 2010
Award Type: Standard
Award Amount: $400,000


Summary:

The focus of the current proposal is to determine the role of CX3CR1 plays in activation of the immune system, neuronal cell death and Aß deposition in two different mouse models of AD as well as to gain insight into the mechanisms involved. The long-term goal of this project is to gain insight into the role inflammation play in AD and thus provide potential new avenues of therapeutic intervention.

Details:

Alzheimer's disease (AD), the most common dementing disorder of late life, is now the fourth major cause of death in the developed world. A definitive diagnosis of AD requires examination of brain tissue for the presence of distinctive AD pathological alterations including filamentous inclusions (termed neurofibrillary tangles) and extracellular deposits of the ß-amyloid peptide (Aß, termed senile plaques). In addition, while there is considerable data that suggests there is a marked activation of the immune system within the AD brain, there is little evidence that altered inflammation plays a direct role in the observed neurodegeneration. It was recently demonstrated that alterations in inflammation within the brain, through genetically engineered mutations in the chemokine receptor, CX3CR1, can directly result in increased neuronal cell loss in three different mouse models of neurodegeneration. The focus of the current proposal is to determine the role of CX3CR1 plays in activation of the immune system, neuronal cell death and Aß deposition in two different mouse models of AD as well as to gain insight into the mechanisms involved. The long-term goal of this project is to gain insight into the role inflammation play in AD and thus provide potential new avenues of therapeutic intervention.