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Alzheimer's Disease Research - Current Award

Dr. Paul Axelsen

Paul Axelsen, M.D.

University of Pennsylvania
Philadelphia, PA

Title: Oxidative stress and amyloidogenesis
Non-Technical Title: The chemistry of Alzheimer's disease

Duration: April 1, 2008 - March 31, 2009
Award Type: Pilot
Award Amount: $150,000


Summary:

Oxidative stress and amyloid fibril formation are consistent major themes among processes thought to be involved in the pathogenesis of Alzheimer's disease. However, a mechanistic link between these two processes has not been defined. The research being proposed will probe human brain tissues and animal models of Alzheimer's disease for evidence of a specific chemical mechanism that will be amenable to therapeutic intervention.

Details:

Oxidative stress and amyloid fibril formation are consistent major themes among processes thought to be involved in the pathogenesis of Alzheimer's disease. However, a mechanistic link between these two processes has not been defined. The research being proposed will probe human brain tissues and animal models of Alzheimer's disease for evidence of a specific chemical mechanism that will be amenable to therapeutic intervention.