Text Size Normal Text Sizing Button Medium Text Sizing Button Large Text Sizing Button Text Contrast Normal Contrast Button Reverse Contrast Button Switch to Spanish Language Contact Us Sitemap Sign In Register
Link to Homepage About AHAF
Donate Now Get Involved  
Alzheimer's Disease Research Macular Degeneration Research National Glaucoma Research


Sign up for Email Notifications
If you would like to be notified when submission deadlines are announced please click on the link below.

Sign up for new RFP announcements and submission deadline notifications.

This email list is not sold or distributed, and serves only as an annual reminder of the availability of research funding through the American Health Assistance Foundation (www.ahaf.org). Please follow instructions on the notification emails for removal requests.
 
AHAF Research Grants Funding
Grant Funding for Alzheimer's Research
Grant Funding for Macular Degeneration Research
Grant Funding for Glaucoma Research
 

  

Alzheimer's Disease Research - Current Award

Photo Pending

Alan Lerner, M.D.

University Hospitals of Cleveland
Cleveland, OH

Title: Teen IQ, Activity Level, and AD: Mechanisms of the Links
Non-Technical Title:

Duration: April 1, 2006 - March 31, 2010
Award Type: Pilot
Award Amount: $85,500

Details:

Studies have suggested that low cognitive performance and low activity level in youth may be associated with an increased risk for dementia in adulthood. However, we know little about the mechanism(s) underlying the associations. Experiences occurring in mid- and late-life could mediate the influence of cognitive ability and activity level in youth on cognitive function in adulthood. Or, the effects of early life factors on AD could be independent of mid- and late-life experiences. In this project, Dr. Lerner will examine the relationships between teen IQ and activity level, and a genetic risk factor for AD (APOE e4), on the development of AD over time. Subjects will be 1940s graduates of the same high school who had normal cognition in 2002. Subjects will undergo two follow-up evaluations to detect transitions to dementia. IQ test scores and activity levels, gathered from sources at the school, will be used as predictor variables in statistical models. Dr. Lerner predicts that lower IQ and activity level, and the high-risk APOE gene will each increase AD risk, and that mid- and late-life factors will directly and indirectly contribute to this effect. These findings will contribute to knowledge about pathways leading to AD and may identify modifiable risk factors.