Text Size Normal Text Sizing Button Medium Text Sizing Button Large Text Sizing Button Text Contrast Normal Contrast Button Reverse Contrast Button Switch to Spanish Language Contact Us Sitemap Sign In Register
Link to Homepage About AHAF
Donate Now Get Involved  
Alzheimer's Disease Research Macular Degeneration Research National Glaucoma Research


Sign up for Email Notifications
If you would like to be notified when submission deadlines are announced please click on the link below.

Sign up for new RFP announcements and submission deadline notifications.

This email list is not sold or distributed, and serves only as an annual reminder of the availability of research funding through the American Health Assistance Foundation (www.ahaf.org). Please follow instructions on the notification emails for removal requests.
 

Researchers:
Have you heard a story, statistic, or discovery that might interest the public? Let us know about it!
 
AHAF Research Grants Funding
Grant Funding for Alzheimer's Research
Grant Funding for Macular Degeneration Research
Grant Funding for Glaucoma Research
 

  

Macular Degeneration Research - Completed Award

Photo Pending

Neal Peachey, Ph.D.

The Cleveland Clinic Foundation
Cleveland, OH

Title: The Role of Complement Regulation in Maintaining Outer Retinal Integrity
Non-Technical Title: Role of Complement Regulation in Age-Related Macular Degeneration

Duration: April 1, 2008 - March 31, 2010
Award Type: Standard
Award Amount: $100,000


Summary:

The main goal of the study is to examine the phenotype of MCP1-/DAF- double knockout mice and to test whether light exposure exacerbates the phenotype.

Details:

Several genes implicated in AMD are known to be involved in the complement pathways of the immune system. The researchers will compare the severity of outer retinal defects in a mouse model of AMD due to the absence of the MCP1 (monocyte chemoattractant protein-1) gene with those found in mice also lacking one of two proteins involved in complement regulation. They will test whether complement regulation is important for maintaining outer retinal integrity. They will also test whether biochemicals normally generated in the outer retina by the interaction of photoreceptor proteins, light and oxygen trigger development of outer retinal abnormalities.