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Alan Marmorstein, Ph.D.
University of Arizona
Tucson, AZ
Title:
Bestrophin-2 And Aqueous Humor Dynamics
Non-Technical Title:
Bestrophin-2 Protein And Glaucoma
Duration:
April 1, 2009 - March 31, 2011
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Summary: This study seeks to determine how the Bestrophin-2 protein controls the flow of the fluid in the eye, the aqueous humor.
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Program: Glaucoma
Award Type: Standard
$100,000
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Thao Nguyen, Ph.D.
Johns Hopkins University
Baltimore, MD
Title:
The Biomechanics of the Mouse Sclera: Effects of Strain, Age, and Glaucoma
Non-Technical Title:
Biomechanics of Glaucoma in Mouse Models
Duration:
April 1, 2010 - March 31, 2012
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Summary: Numerous studies have suggested an association between scleral biomechanical alterations and optic nerve dysfunction. Our ultimate goal is to determine how the mechanical properties of the sclera, the white portion of the eye, influence the development of glaucoma optic nerve damage and how the development of glaucoma damage in turn alters the mechanical properties of the sclera. Towards this goal, we are developing an inflation test to characterize and compare the mechanical behavior of the sclera of a glaucoma mouse model and its genetically matched control.
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Program: Glaucoma
Award Type: Standard
$99,182
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Ron Ofri, Ph.D.
Hebrew University of Jerusalem
Jerusalem, Israel
Title:
Expression of ion channels during ganglion cell apoptosis. Implications for the pathogenesis of glaucomatous optic neuropathy and relevance for neuroprotective treatment
Non-Technical Title:
The role of electric current changes in loss of vision in glaucoma patients, and their implication for treatment
Duration:
April 1, 2008 - March 31, 2011
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Summary: This study investigates the ability of an epilepsy drug to reduce cell death related to glaucoma.
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Program: Glaucoma
Award Type: Standard
$100,000
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Darryl Overby, Ph.D.
Imperial College London
London, England
Title:
Role Of Inner Wall Basement Membrane In Outflow Resistance
Non-Technical Title:
How Does The Eye Control Its Pressure?
Duration:
April 1, 2009 - March 31, 2011
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Summary: What controls intraocular pressure? It is surprising that we still have no answer to this important question. The Specific Aims of our research will determine how intraocular pressure may be regulated by the basement membrane underlying the inner wall endothelium of Schlemm's canal.
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Program: Glaucoma
Award Type: Standard
$100,000
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Susanne Ragg, M.D., Ph.D.
Indiana University School of Medicine
Indianapolis, IN
Title:
An Integrated Approach to Proteomic Analysis of Aqueous Humor
Non-Technical Title:
Determination of aqueous humor proteins in glaucoma
Duration:
April 1, 2010 - March 31, 2012
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Summary: Our research will address the question of what protein signaling pathways in the anterior segment of the eye are abnormal in glaucoma. By identifying the critical protein profiles that distinguish eyes with glaucoma from normal eyes, we are gaining significant insight into what causes elevated intraocular pressure in glaucoma.
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Program: Glaucoma
Award Type: Standard
$100,000
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Paul Russell, Ph.D.
The Regents of the University of California-Davis
Davis, CA
Title:
Biophysical Cues, Antioxidants and Trabecular Meshwork
Non-Technical Title:
Antioxidant Status and the Progression of Glaucoma
Duration:
April 1, 2010 - March 31, 2012
Co-Investigator(s):
Christopher Reilly,
The Regents of the University of California-Davis
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Summary: The capacity of trabecular meshwork cells to resist oxidative stress is reduced in glaucoma. Research to investigate this loss in protection of the cells has disregarded the importance of biophysical cues in contributing to the antioxidant status. This study examines the contribution of nanoscale surface features and biomechanics to the total antioxidant status of these cells.
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Program: Glaucoma
Award Type: Standard
$100,000
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Joel Schuman, M.D.
University of Pittsburgh
Pittsburgh, PA
Title:
Spectral Domain OCT Doppler Assesses Aqueous Outflow
Non-Technical Title:
A New Non-Contact Measurement of the Process that Controls Eye Pressure
Duration:
April 1, 2010 - March 31, 2012
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Summary: The most important factor to consider in glaucoma is the pressure of the eye, which is controlled by the slow outflow of fluid within a drainage system in the front of the eye. We have developed a way to visualize and measure how fast this drainage occurs without touching the eye, and without any bright lights. This project is vital in two ways: 1- in order to validate the new measurement in a controlled environment designed to be nearly identical to that of the clinic, and 2- in order to finally visualize, for the first time, the entire system as it functions.
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Program: Glaucoma
Award Type: Standard
$100,000
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Arthur Sit, M.D.
Mayo Clinic College of Medicine
Rochester, MN
Title:
Characterization of Episcleral Venous Pressure in Humans
Non-Technical Title:
Measuring pressure in the eye's veins: a key to understanding glaucoma
Duration:
April 1, 2010 - March 31, 2012
Co-Investigator(s):
Jay McLaren,
Mayo Clinic College of Medicine
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Summary: Measurement of episcleral venous pressure is critical to understanding the changes in intraocular pressure that occur in normal and glaucomatous eyes, but no reliable method has previously been available for human use, resulting in an incomplete understanding of aqueous humor dynamics. We have developed a new technique and device to allow precise and accurate measurement of episcleral venous pressure by providing reproducible measurement endpoints. In this project, we further develop the technique and analysis software so that it is suitable for large scale projects, enabling future investigations into episcleral venous pressure and aqueous humor dynamics in normal subjects and glaucoma patients.
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Program: Glaucoma
Award Type: Standard
$100,000
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Ian Trounce, Ph.D.
Centre for Eye Research Australia, The University of Melbourne
Melbourne, Australia
Title:
The Effect Of Glaucoma Risk Factors On APP Processing In Retinal Ganglion Cells
Non-Technical Title:
Alzheimer’s Disease Proteins In Glaucoma
Duration:
April 1, 2009 - March 31, 2011
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Summary: This study aims to study the influence of high eye pressure and increasing age, the two major risk factors for glaucoma, on how the "Alzheimer’s disease" protein “amyloid precursor protein” (APP) breaks down. These experiments will shed light on whether age-related changes in the way this protein functions account for the vulnerability of older eyes to glaucoma. If this is the case, then further work aimed at restoring APP will likely prove fruitful in developing new treatments for glaucoma.
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Program: Glaucoma
Award Type: Standard
$94,834
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Jonathan Vande Geest, Ph.D.
University of Arizona
Tucson, AZ
Title:
Microstructural And Biomechanical Properties Of Human Sclera
Non-Technical Title:
Organization And Properties Of The Human Sclera And Its Relation To Glaucoma
Duration:
April 1, 2009 - March 31, 2011
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Summary: This research is aimed at identifying whether changes in peripapillary human scleral microstructure and mechanical properties occur within human donor eyes of varying ages, races, and in the presence or absence of glaucoma. Such information will be important in quantifying the biomechanical environment of the optic nerve head. These studies may also eventually lead to improved diagnostic tools for glaucoma.
More details
Program: Glaucoma
Award Type: Standard
$100,000
