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Carla Siegfried, M.D.
Washington University
St. Louis, MO
Title:
Aqueous Humor Oxidative Stress Markers in Glaucoma
Non-Technical Title:
Oxidative damage in the eye
Duration:
April 1, 2007 - March 31, 2010
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Summary: Our proposed study will examine the aqueous humor, the fluid in the front of the eye, of patients who are undergoing eye surgery. We will measure both a byproduct (hydrogen peroxide) and a protectant (ascorbic acid) of oxidative damage, as well as oxygen levels in different parts of the front of the eye. By aiding in further understanding of this oxidative mechanism of glaucoma damage, it may lead to innovative therapies for this devastating condition.
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Program: Glaucoma
Award Type: Standard
$90,000
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Ian Trounce, Ph.D.
Centre for Eye Research Australia, The University of Melbourne
Melbourne, Australia
Title:
The Effect Of Glaucoma Risk Factors On APP Processing In Retinal Ganglion Cells
Non-Technical Title:
Alzheimer’s Disease Proteins In Glaucoma
Duration:
April 1, 2009 - March 31, 2011
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Summary: This study aims to study the influence of high eye pressure and increasing age, the two major risk factors for glaucoma, on how the "Alzheimer’s disease" protein “amyloid precursor protein” (APP) breaks down. These experiments will shed light on whether age-related changes in the way this protein functions account for the vulnerability of older eyes to glaucoma. If this is the case, then further work aimed at restoring APP will likely prove fruitful in developing new treatments for glaucoma.
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Program: Glaucoma
Award Type: Standard
$94,834
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Jonathan Vande Geest, Ph.D.
University of Arizona
Tucson, AZ
Title:
Microstructural And Biomechanical Properties Of Human Sclera
Non-Technical Title:
Organization And Properties Of The Human Sclera And Its Relation To Glaucoma
Duration:
April 1, 2009 - March 31, 2011
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Summary: This research is aimed at identifying whether changes in peripapillary human scleral microstructure and mechanical properties occur within human donor eyes of varying ages, races, and in the presence or absence of glaucoma. Such information will be important in quantifying the biomechanical environment of the optic nerve head. These studies may also eventually lead to improved diagnostic tools for glaucoma.
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Program: Glaucoma
Award Type: Standard
$100,000
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Judith West-Mays, Ph.D.
McMaster University
Hamilton, Canada
Title:
The Roles of MMPs in TGFbeta induced Glaucoma
Non-Technical Title:
MMPs in Glaucoma
Duration:
April 1, 2008 - March 31, 2010
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Summary: Researchers on this project will examine how eyes with glaucoma differ molecularly from normal eyes. They will specifically focus on the roles of MMPs, which are proteins that limit scarring in the eye. They hypothesize that increasing the activity of MMPs may be a treatment option for glaucoma symptoms.
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Program: Glaucoma
Award Type: Standard
$100,000
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Bernd Wissinger, Ph.D.
Institute for Ophthalmic Research
Tuebingen, Germany
Title:
Identification Of Genetic Risk Factors In Pigmentary Glaucoma
Non-Technical Title:
Genetic Factors In Pigmentary Type Glaucoma
Duration:
April 1, 2009 - March 31, 2011
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Summary: We focus on the identification of genetic risk factors of a type of glaucoma, termed pigmentary glaucoma by using two screening strategies that complement each other in an ideal way. Candidate genes were selected based on identification of related genes in different mouse models exhibiting pigment dispersion and based on pathway and protein-protein interaction annotations. These candidate genes will be subjected to a technique called direct mutation scanning AND will be analyzed by means of a case control study.
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Program: Glaucoma
Award Type: Standard
$100,000
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Beatrice Yue, Ph.D.
University of Illinois at Chicago
Chicago, IL
Title:
Functional Roles of Optineurin in RGC-5 cells
Non-Technical Title:
Functions of Optineurin, a Glaucoma Gene
Duration:
April 1, 2008 - March 31, 2010
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Summary: This study examines how proteins are transported inside cells and how neurites grow. The study may enhance understanding of mechanisms leading to neuronal cell loss in glaucoma and facilitate development of new treatments for glaucoma.
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Program: Glaucoma
Award Type: Standard
$100,000
