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Judith West-Mays, Ph.D.
McMaster University
Hamilton, Canada
Title:
The Roles of MMPs in TGFbeta induced Glaucoma
Non-Technical Title:
MMPs in Glaucoma
Duration:
April 1, 2008 - November 30, 2010
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Summary: Researchers on this project will examine how eyes with glaucoma differ molecularly from normal eyes. They will specifically focus on the roles of MMPs, which are proteins that limit scarring in the eye. They hypothesize that increasing the activity of MMPs may be a treatment option for glaucoma symptoms.
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Program: Glaucoma
Award Type: Standard
$100,000
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Bernd Wissinger, Ph.D.
Institute for Ophthalmic Research
Tuebingen, Germany
Title:
Identification Of Genetic Risk Factors In Pigmentary Glaucoma
Non-Technical Title:
Genetic Factors In Pigmentary Type Glaucoma
Duration:
April 1, 2009 - October 31, 2011
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Summary: We focus on the identification of genetic risk factors of a type of glaucoma, termed pigmentary glaucoma by using two screening strategies that complement each other in an ideal way. Candidate genes were selected based on identification of related genes in different mouse models exhibiting pigment dispersion and based on pathway and protein-protein interaction annotations. These candidate genes will be subjected to a technique called direct mutation scanning AND will be analyzed by means of a case control study.
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Program: Glaucoma
Award Type: Standard
$100,000
